刘洁，女，药物化学专业博士，副教授，硕士生导师。2004年本科毕业于中国·太阳娱乐古天乐(大股东)股份公司理科基地专业，2009年获得中国·太阳娱乐古天乐(大股东)股份公司药物化学专业博士学位，同年留校任教于古天乐是太阳娱乐大股东有机化学教研室。于2014年9月至2015年9月作为访问学者赴澳大利亚莫纳什大学进行为期一年的研究工作, 2015年晋升为副教授。现主要研究方向为，以天然产物为先导化合物，进行新型多耙点药物的设计与合成；利用计算机辅助药物设计，在小分子库中寻找新型心血管药物、神经系统药物、抗肿瘤药物结构，并作为先导化合物，进行构效关系研究，同时研究其与靶点的作用模式，从而进一步寻找获得新型心血管药物、神经系统药物和抗肿瘤药物分子的新药候选化合物。先后主持国家自然科学基金青年项目1项，参与国家自然科学基金面上项目2项，国家重点实验室基金２项。在药物化学和有机化学多个重要SCI期刊发表论文20余篇，申请发表专利多项。
近年发表的主要论文：
1.Lixue Lu, Hengyuan Zhang, Jie Liu*, Yang Liu, Yiwei Wang, Shengtao Xu, Zheying Zhu, Jinyi Xu*. Synthesis, biological evaluation and mechanism studies of C-23modified 23-hydroxybetulinic acid derivatives as anticanceragents. European Journal of Medicinal Chemistry, 2019,182, 111659-70.
2.Shaowen Xie, Xinnan Li, Hao Yu, Pengfei Zhang, Jia Wang, Chaolei Wang, Shengtao Xu, Zheng Wu, Jie Liu*, Zheying Zhu, Jinyi Xu*. Design, synthesis and biological evaluation of isochroman-4-one hybrids bearing piperazine moiety as antihypertensive agent candidates. Bioorganic & Medicinal Chemistry, 2019, 27, 2764-70.
3.Chaolei Wang, Zheng Wu, Jia Wang, JieLiu,* Hequan Yao, Aijun Lin and Jinyi Xu*. An efficient synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide. Tetrahedron 2015, 71, 8172-8177.
4.Chaolei Wang, Zheng Wu, Hao Cai, Shengtao Xu, Jie Liu,* Jieyun Jiang, Hequan Yao, Xiaoming Wu, Jinyi Xu*. Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrides bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors. Bioorg. Med. Chem. Lett..2015, 25(22):5212-5216.
5.Chaolei Wang, Guoxiang Wei, Yue Huang, Xue Yang, Hequan Yao, Jieyun Jiang, Jie Liu*, Mingqin Shen, Xiaoming Wu, Jinyi Xu*. First total synthesis of antihypertensive naturalproducts S-(+)-XJP and R-(−)-XJP. Organic&BiomolecularChemistry,2014,12(37):7338-44.
6.Renren Baia, Xiaojing Huang, Xue Yang, Wen Hong, Yiqun Tang, Hequan Yao, Jieyun Jiang, Jie Liu*, Mingqin Shen, Xiaoming Wu,* Jinyi Xua. * Novel hybrids of natural isochroman-4-one bearing N-substitutedisopropanolamine as potential antihypertensive candidates.Bioorganic & Medicinal Chemistry, 2013, 21, 2495-2502.
7.Renren Bai , Xue Yang , Yao Zhu , Zhiwen Zhou , Weijia Xie , Hequan Yao , Jieyun Jiang , Jie Liu* , Mingqin Shen , Xiaoming Wu, Jinyi Xu* . Novel nitric oxide-releasing isochroman-4-one derivatives: synthesis and evaluation of antihypertensive activity. Bioorg. Med. Chem. 2012(20)6848-6855.
8.Renren Bai , Jie Liu# , Yao Zhu , Xue Yang , Chen Yang,Lingyi Kong ,Xiaobing Wang, Hengyuan Zhang , Hequan Yao , Mingqin Shen d, Xiaoming Wu,Jinyi Xu. Chiral separation, configurational identification and antihypertensive evaluation of (±)-7,8-dihydroxy-3-methyl-isochromanone-4. Bioorg. Med. Chem. Lett. 2012, 22, 6490-6493.